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Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways

A century ago, three-quarters of prescriptions required some sort of in-pharmacy compoundingmixing up drug formulations in the shop rather than giving a patient a standard off-the-shelf medicationbut that number dropped to 1% by the 1970s

This analysis excluded trials in those with end-stage renal disease, who are at high risk of cardiovascular events and mortality

PMID: 10791689

The breakdown process appears to generate toxic intermediates or local concentrations of the proapoptotic domain that damage tubular cells